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175 Arginine-succinate synthetase 1 (ASS1) transcriptional repression occurs in various tumors, creating a dependence on external arginine and enabling arginine-deprivation therapy

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eNOS uncoupling Under certain conditions, eNOS can become uncoupled, shifting from producing NO to generating superoxide (O 2 ), which not only reduces NO availability but also increases oxidative stress, reducing endothelial dysfunction

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Agarwal S, Rao AV